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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Original Research
The regulation network and network motif analysis in ovarian cancer
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1
Department of Reproductive Medicine, Renji Hospital, Shanghai Jliaotong University, School of Medicine, Shanghai (China)
Eur. J. Gynaecol. Oncol. 2013, 34(2), 170–174;
Published: 10 April 2013
Abstract
Objective: Several gene alterations have been identified associated with ovarian cancer (OC) development. However, how these genetic elements are coordinated in transcription network during OC initiation and progression is poorly understood. Thus, the objective of this study was to interpret the transcription regulation network of OC. Materials and Methods: The GSE14407 microarray data was used for analysis of the transcription regulation network of OC. Results: The results showed that the TP53 (tumor protein p53) was the most crucial transcription factor in the transcriptome network. P53 could down-regulate CDC14A (CDC14 cell division cycle 14 homolog A [S. cerevisiae]) and FAS (TNF receptor superfamily, member 6) expression, but up-regulate SFN (stratifin) and THBS1 (thrombospondin 1) expression to involve in pathways in cancer, cell cycle, p53 signaling pathway, and apoptosis pathway. Conclusion: This transcriptional regulation may provide a better understanding of molecular mechanism and some potential therapeutic targets in the treatment of OC.
Keywords
Regulation network
Network motif analysis
Ovarian cancer