IMR Press / EJGO / Volume 34 / Issue 2 / pii/1630905778174-1181216865

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
The correlation between expression of synuclein-γ, glucose transporter-1, and survival outcomes in endometrioid endometrial carcinoma
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1 Gynecologic Cancer Center, Kyungpook National University Medical Center, Daegu
2 Department of Mathematics, Korea Science Academy of Korea Advanced Institute of Science and Technology, Pusan
3 Department of Pathology, Kyungpook National University Medical Center, Daegu (Republic of Korea)
Eur. J. Gynaecol. Oncol. 2013, 34(2), 128–131;
Published: 10 April 2013
Abstract

Purpose: To evaluate the correlation between immunohistochemical expression of synuclein-γ, glucose transporter-1, and survival outcomes in endometrioid endometrial carcinoma. Materials and Methods: A tissue microarray was constructed using formalinfixed, paraffin-embedded tissue that included 23 early and 18 advanced cases. The intensity and area of the immunohistochemical reactions were evaluated using the semi-quantitative scoring system. Results: Synuclein-γ expression was higher in the advanced stage, although it was not statistically significant (p = 0.51). Glucose transporter-1 was overexpressed in the advanced stage (p = 0.01). Synuclein-γ (score = 0 vs > 0) and glucose transporter-1 (score ≤ 7 vs > 7) did not show any differences in overall survival (p = 0.54, p = 0.48) and disease-free survival (p = 0.61, p = 0.14). Conclusion: In this study the expression of synuclein-γ and glucose transporter-1 were not considered to be a prognostic factor and were not related with survival outcomes in endometrioid endometrial carcinoma.
Keywords
Endometrial carcinoma
Synuclein-γ
Glucose transporter-1
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