European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Cite this article
Prognostic value of lymph node status and number of removed nodes in patients with squamous cell carcinoma of the vulva treated with modified radical vulvectomy and inguinal-femoral lymphadenectomy
A. Gadducci1,*, A. Ferrero2, R. Tana1, M.G. Fabrini3, P. Modaffari2, A. Fanucchi1, C. Vignati1, P. Zola2
1 Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa
2 Department of Gynecology and Obstetrics, University of Turin, Mauriziano Hospital, Turin
3 Department of Oncology, Division of Radiation Oncology, University of Pisa, Pisa (Italy
Eur. J. Gynaecol. Oncol. 2012, 33(6), 640–643;
Published: 10 December 2012
Purpose of investigation: To assess the outcome of patients with squamous cell vulvar carcinoma treated with deep partial or total vulvectomy and inguinal-femoral lymphadenectomy. Materials and Methods: The authors assessed 87 patients who underwent primary surgery. Results: Tumor recurred in 34 patients, and the first relapse was local in 19, inguinal in ten, and distant in five. Fiveyear disease-free survival was 56.7% and was related to Stage (p < 0.0001), grade (p = 0.023), and node status (p < 0.0001). Groin failure occurred in 4.9% of node-negative patients compared with 29.6% of node-positive patients (p = 0.0096). Distant recurrences only developed in women with positive nodes. Among the 47 patients who underwent bilateral lymphadenectomy and who had negative nodes, groin recurrence occurred in 12% of those who had ≤15 nodes removed and 0% of those who had >15 nodes removed. Conclusions: Stage and node status were the most important prognostic variables. There was a trend favoring a better groin control in patients with node-negative disease who underwent extensive lymphadenectomy.