IMR Press / EJGO / Volume 33 / Issue 4 / pii/1631087288444-2041416360

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Case Report
Large cell neuroendocrine carcinoma arising in mature cystic teratoma: a case report and review of the literature
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1 Department of Obstetrics and Gynecology, National Defense Medical College, Tokorozawa (Japan)
Eur. J. Gynaecol. Oncol. 2012, 33(4), 414–418;
Published: 10 August 2012

Background: Malignant transformation of ovarian mature cystic teratoma is rare, and occurs in approximately 1% of all cases. The most common histology arising in mature cystic teratoma is squamous cell carcinoma. Less frequently, malignant transformation is represented by an endocrine tumor. To date, only five cases of large cell neuroendocrine carcinoma (LCNC) arising in a mature cystic teratoma of the ovary have been reported. Clinical case: A 69-year-old woman presented with a 15-cm left ovarian mass, and was diagnosed with Stage IV large cell carcinoma neuroendocrine carcinoma (LCNC) arising in mature cystic teratoma (MCT) of the left ovary. The patient received adjuvant chemotherapy with paclitaxel and carboplatin, however, residual tumors increased in size. Six months after the debulking surgery she succumbed to the disease. A literature review revealed LCNC of the ovary showed excessively aggressive phenotype in malignant transformation from ovarian mature cystic teratoma. Conclusion: The present case of LCNC arising in MCT had an exceedingly poor prognosis, which was suggested in the previous five cases reported.
Ovarian tumor
Mature cystic teratoma
Large cell neuroendocrine carcinoma
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