IMR Press / EJGO / Volume 33 / Issue 3 / pii/1631086574047-1724655601

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Evaluation of endometrium by transvaginal ultrasonography and Doppler in tamoxifen-treated women with breast cancer
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1 Department of Obstetrics and Gynecology, Izmir Ataturk Training and Research Hospital, Izmir
2 Department of Medical Oncology; 3Department of Radiology, Izmir Ataturk Training and Research Hospital, Izmir
3 Department of Pathology, Izmir Ataturk Training and Research Hospital, Izmir (Turkey)
Eur. J. Gynaecol. Oncol. 2012, 33(3), 295–299;
Published: 10 June 2012

Purpose: The purpose of this study was to investigate the discriminative role of transvaginal ultrasonography and Doppler measurements on the detection of endometrial pathologies in tamoxifen-treated breast cancer patients. Methods: Tamoxifen-treated breast cancer patients were included in this prospective study between February 2009 and June 2010. The subjects were assessed by gynecologic examination and transvaginal gray-scale and Doppler sonography. The patients whose endometrial thicknesses were more than 6 mm underwent endocervical/endometrial curettage for histopathological examination. Results: There were 98 tamoxifen-treated patients with breast cancer enrolled in the study, providing 141 ultrasound evaluations. Uterine artery pulsatility index was significantly lower in postmenopausal than premenopausal patients (p: 0.013). Endocervical and endometrial curettage was performed in 52 patients. It was more prevalent that the endometrial strip was ≥6 mm in women with abnormal endometrial histopathology (p: 0.020). However the women with abnormal endometrial histopathology presented lower vascular indices; the only significant difference was in myometrial pulsatility index (p: 0.036). Conclusion: The most evident tool for evaluating the endometrium in tamoxifen-treated breast cancer patients is still the transvaginal measurement of its thickness. It exists that Doppler ultrasonographic assessment of uterine, radial and spiral vasculature has no additional benefit for detection of endometrial pathology.
Doppler ultrasonography
Endometrial thickness
Transvaginal ultrasonography
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