European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Cite this article
The role of surgery in patients with advanced gynaecological cancers participating in phase I clinical trials
J. Vitfell-Pedersen1, T. A. Yap1, V. Moreno1, R. D. Baird1, A. Z. Khan1, D. P. J. Barton1, S. B. Kaye1.*
1 Drug Development Unit, The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey (UK)
Eur. J. Gynaecol. Oncol. 2012, 33(2), 211–213;
Published: 10 April 2012
Objective: While gynaecological cancer patients who participate in Phase I clinical trials are not routinely considered for elective surgery because of a short life expectancy, this should not be overlooked in carefully selected responding patients. Methods/Results: We describe two cases of patients with different gynaecological cancers, who received treatment within separate phase I trials, and who then proceeded to surgical resection of their cancers, resulting in complete remission. Conclusion: Surgery, when feasible, should be taken into consideration as a potential management option, even when patients are receiving treatment within a phase I trial.
Phase I trial