IMR Press / EJGO / Volume 33 / Issue 2 / pii/1631086378325-309931360

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Correlation between preoperative endometrial sampling and final endometrial cancer histology
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1 Pan-Birmingham Gynaecology Cancer Centre, Sandwell and West Birmingham NHS Trust (UK)
Eur. J. Gynaecol. Oncol. 2012, 33(2), 142–144;
Published: 10 April 2012
Abstract

Objective: We conducted a study to evaluate the correlation between pre-operative endometrial sampling to the final endometrial cancer histology, in particular the non-endometrioid subtypes. Methods: This involved 191 hysterectomy specimens of patients undergoing treatment at the Pan-Birmingham Gynaecological Regional Cancer Centre (BGCC) over a two-year period (2006-2007). Results: The majority of the patients in this study were found to have endometrioid histology subtype (140/191, 73%). However, the non-endometrioid histologic subtypes were well presented in our population (51/191, 27%). We found good correlation for endometriod histology subtype (78%) and certain types of the non-endometrioid cell types (carcinosarcoma 90%, uterine papillary serous carcinoma 67%, clear cell carcinoma 67%) but poor in sarcomas (40%). Our results also demonstrated that both pre-operative endometrial sampling methods (curettage and pipelle biopsy) were reliable in identifying endometrioid and non-endometrioid cancer cell types, with sensitivities of 96.5% and 86.5%, respectively. Conclusion:We concluded that preoperative endometrial sampling had good overall histological correlation to hysterectomised corpus specimen. This is especially so for the endometrioid and certain subtypes of the non-endometrioid endometrial cancer cells.
Keywords
Complex atypical hyperplasia
Endometrial carcinoma
Endometrial sampling
Post menopausal bleeding
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