IMR Press / EJGO / Volume 33 / Issue 1 / pii/1631086206051-770735141

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Case Report
Perivascular epithelioid cell tumor (PEComa) of gynecologic origin: a clinicopathological study of three cases
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1 Department of Gynecology and Obstetrics, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou
2 Department of Pathology, Guangdong General Hospital, Guangzhou
3 Medical research Center, Guangdong General Hospital, Guangzhou (China)
Eur. J. Gynaecol. Oncol. 2012, 33(1), 105–108;
Published: 10 February 2012
Abstract

Perivascular epithelioid cell tumors (PEComas), occasionally associated with the tuberous sclerosis complex, are characterized by varying amounts of spindle and epithelioid cells with clear to eosinophilic cytoplasm that display immunoreactivity for melanocytic markers, most frequently HMB-45. Perivascular epithelioid cell tumor of gynecologic origin is very rare, and there have been only a few reported cases. This study describes the clinical, histological, and immunohistochemical features and prognoses of three cases of gynecologic origin. Two of the three tumors were confined to the uterus and one to the vagina. None of the patients had tuberous sclerosis complex. Immunohistochemistry indicated that all three cases expressed at least one melanocytic marker, and HMB45 was a positive marker for all of them. These markers can be found in both epithelial cells and spindle cells. Except for MiTF, which was located in the nucleus, all the other antibodies were located in the cytoplasm. The three cases have been followed up for 26, 22, and three months, respectively, with disease-free survival in all cases. We conclude that PEComas of gynecologic origin have morphological and immunohistochemical features of the PEComa family, which are rare and should be included in the differential diagnosis with other tumors. Until more cases of this rare tumor are evaluated with longer follow-up, firm criteria for malignancy remain uncertain.
Keywords
PEComa
Perivascular epithelioid cell tumors
Gynecologic origin
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