IMR Press / EJGO / Volume 33 / Issue 1 / pii/1631086194556-1933838932

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
3D optical coherence tomography of cervical intraepithelial neoplasia - early experience and some pitfalls
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1 Department of Obstetrics and Gynecology, Ludwig-Maximilians University, Munich
2 Laser Forschungs Labor, Life Science Centre, Ludwig-Maximilians University, Munich (Germany)
Eur. J. Gynaecol. Oncol. 2012, 33(1), 37–41;
Published: 10 February 2012
Abstract

Objectives: To compare two different systems for optical coherence tomography for the diagnosis of cervical dysplasia and to assess potential benefits of three-dimensional imaging. Materials and Methods: OCT images were taken from unsuspicious and suspicious areas of fresh conisation specimens using two different imaging systems, one with the capability to produce three-dimensional images. All OCT images were separately evaluated by two blinded investigators based on a 6-grade classification (normal, inflammation, CIN 1, CIN 2, CIN 3, squamous carcinoma) and later compared to the corresponding histology. Sensitivity and specificity of OCT in detecting cervical dysplasia were determined. Results: OCT images using both OCT systems were taken from 46 sites in ten conisation specimens and later compared to the corresponding histology. CIN lesions were diagnosed correctly by the two-dimensional OCT system with a sensitivity and specificity of 91% and 78% accordingly. Using the three-dimensional system sensitivity and specificity were 82% and 86% accordingly. Conclusions: Both OCT systems used were highly sensitive in identifying cervical intraepithelial neoplasia. Despite technical problems experienced in the present series, we believe that three-dimensional imaging has the potential to further improve the accuracy of optical coherence tomography.
Keywords
Optical coherence tomography
OCT
Colposcopy
Intraepithelial cervical dysplasia
CIN
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