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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Is magnetic resonance imaging useful in early evaluation of women on neoadjuvant chemotherapy for locally advanced cervical cancer?
P. Sala1,*, P. Marchiolè Marchiolè2, G. Cittadini3, M. Valenzano Menada1, M. Moioli1, S. Mammoliti4, S. Costantini1
1 Operative Unit of Clinical Obstetrics and Gynecology, San Martino Hospital, University of Genoa
2 Department of Gynecology and Obstetrics, Villa Scassi Hospital-ASL3, Genoa
3 Department of Radiology, San Martino Hospital, University of Genoa, Genoa
4 Department of Medical Oncology, San Martino Hospital, Genoa (Italy)
Eur. J. Gynaecol. Oncol. 2012, 33(1), 31–36;
Published: 10 February 2012
Objective: To evaluate the accuracy of magnetic resonance imaging (MRI) in staging cervical tumors after neoadjuvant chemotherapy (NACT). Methods: 26 women, affected by locally advanced cervical cancer and triaged for surgery after NACT, were submitted to three cycles of neoadjuvant chemotherapy. All patients were submitted to MRI before and after NACT. We evaluated the MRI sensitivity and specificity in staging cervical tumors after chemotherapy, relating MRI findings after NACT with the pathological findings as the gold standard. Results: In our series, MRI sensitivity was 58.8% and specificity was 66.7%. Conclusions: In our study MRI accuracy after NACT was lower than that of MRI used to stage patients with early cervical cancer scheduled for primary surgery, reported by the literature. MRI false negative cases are the major problem because of the delay in application of an effective therapy in non responders to NACT.
Locally advanced cervical cancer (LACC)
Neoadjuvant chemotherapy (NACT)
Magnetic resonance imaging (MRI)
Early response evaluation
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