IMR Press / EJGO / Volume 32 / Issue 3 / pii/1630980238060-1964329183

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Case Report
Primary squamous cell carcinoma of the endometrium: a case report
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1 Department of Gysnecology and Obstetrics, and Pathophysiology of Human Reproduction
2 Department of Biomorphologic and Functional Sciences, Pathological Anatomy Section, University of Naples “Federico II” (Italy)
Eur. J. Gynaecol. Oncol. 2011, 32(3), 350–352;
Published: 10 June 2011

Background: Primary endometrial squamous cell carcinoma (PSECC) is a rare neoplasm. Squamous epithelium derived from endometrioid cancer or from cervical squamous cell carcinoma. The prevalence is about 0.1%. The genesis, histogenesis and biological behavior are unknown. Case presentation: A 48-year old woman in postmenopause, referring pelvic pain and vaginal bleeding. Transvaginal ultrasound showed a bulky uterus with the endometrium containing an hyperecogenic area. Endometrial biopsy found an epidermoid carcinoma. MRI showed a 4 x 2 x 1.2 cm mass occupying the uterine cavity. The patient underwent radical treatment. Pathological examination showed features of PSECC. The mutation of p53 tumor suppressor protein was disclosed in 15% of neoplastic cells. PCR revealed the absence of HPV DNA. Conclusions: The findings of our case move us to underline that the pathogenesis of this tumor is still unclear. Moreover, preoperative diagnosis and staging of PESCC is extremely difficult. Most patients do not show characteristic symptoms and predisposing factors, making it almost impossible to diagnose the precise localization of tumor origin.
Squamous cell carcinoma
Vaginal bleeding
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