IMR Press / EJGO / Volume 32 / Issue 3 / pii/1630980223547-2088636141

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women
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1 IGEVET (Institute of Veterinary Genetics “Ingeniero Fernando Noel Dulout”) Faculty of Veterinary Science, National University of La Plata, Buenos Aires (Argentina)
Eur. J. Gynaecol. Oncol. 2011, 32(3), 274–279;
Published: 10 June 2011
Abstract

Background: XRCC1 (X-ray repair cross-complementing group 1) plays a central role in the DNA base excision repair mechanism. Single nucleotide polymorphisms (SNPs) in the XRCC1 gene are thought to modulate DNA repair capacity and have been linked to cancer risk in several studies. Materials and Methods:We conducted a case-control study comprising 217 cervical samples, including 103 cervical carcinomas and 114 normal tissue samples. Cervical samples were genotyped for two XRCC1 SNPs (Arg194Trp and Arg399Gln) by PCR-RFLPs. Results: Subjects carrying heterozygous Arg399Gln or the combined Gln399Gln + Arg399Gln variant genotypes had a significantly reduced risk for cervical cancer development. In addition, the 194Arg-399Gln haplotype was also found to be associated with a decreased risk for cervical carcinoma. Conclusion: Our findings suggest that XRCC1 genotypes and haplotypes contribute in reducing the risk for cervical cancer development. Furthermore, genetic susceptibility conferred by Arg399Gln polymorphism operates independently of human papillomavirus infection of cervical tissue.
Keywords
Cervical Cancer
HPV
Single Nucleotide Polymorphisms
XRCC1
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