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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Association of CYP1B1 gene polymorphisms and the positive expression of estrogen α and estrogen β with endometrial cancer risk
Z. Y. Zhu1,*, Y. Q. Mu2, X. M. Fu1, S. M. Li2, F. X. Zhao2
1 Department of Obstetrics and Gynecology, Shanxi Datong University School of Medicine, Datong
2 Institute of Pathogenic Microbiology and Immunology, Shanxi Datong University School of Medicine, Datong (China)
Eur. J. Gynaecol. Oncol. 2011, 32(2), 188–191;
Published: 10 April 2011
To investigate the relationship between the CYP1B1 L432V polymorphism, ERα and ERβ positivities and the incidence of endometrial cancer. The relationship between CYP1B1 L432V polymorphism, ERα and ERβ positivities and endometrial cancer was investigated using the allele-specific polymerase chain reaction method to analyze gene polymorphism in exon 3 codon 432 (C-G) of CYP1B1. Our results are as follows: in endometrial cancer cases the prevalence rates of CYP1B1 L432V genotypes C/C, C/G, and G/G were 47.2%, 36.1%, and 16.7%, respectively, and 68.8%, 23.8% and 7.5% in the control group, respectively. The frequencies of CYP1B1 C and G alleles were 65.3% and 34.7% in endometrial cancer patients and 80.6% and 19.4% in the control group. A significant difference was found in the genotype distributions or allele frequencies of CYP1B1 L432V polymorphism between the two groups (p < 0.05). Compared with wild-type C/C, the susceptibility of endometrial cancer with homozygotic mutation G/G and heterozygotic mutation C/G increased by 3.235 (95%CI 1.111-9.425) and 2.214 (95% CI 1.067-4.593). Moveover, the positive expression of ERα in genotypes G/G and C/G was higher than in the wild genotype C/C (p < 0.05). In conclusion, allelic polymorphism of CYP1B1 L432V increases the risk of endometrial cancer and has a positive correlation with ERα expression.
L432V polymorphism of CYP1B1 gene
ERα and ERβ