IMR Press / EJGO / Volume 32 / Issue 2 / pii/1630979925215-1057120152

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
The role of p16INK4a immunostaining in the risk assessment of women with LSIL cytology: a prospective pragmatic study
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1 Department of Obstetrics & Gynaecology, University Hospital of Ioannina, Ioannina (Greece)
2 Department of Obstetrics and Gynaecology, Central Lancashire Teaching Hospitals, Preston (UK)
3 Department of Obstetrics & Gynaecology, Watford General Hospital, West Hertfordshire Hospitals NHS Trust, London (UK)
4 Second Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki (Greece)
5 Department of Obstetrics and Gynaecology, “Attikon” Hospital, University of Athens (Greece)
6 Department of Cytopathology, “Attikon” Hospital, University of Athens (Greece)
Eur. J. Gynaecol. Oncol. 2011, 32(2), 150–152;
Published: 10 April 2011
Abstract

Background: The detection of high-grade cervical intraepithelial neoplasia (CIN2 or worse) among patients with low-grade cytology (LSIL) is challenging. The aim of this study was to assess the efficacy of p16INK4a in the risk assessment of women with LSIL cytology. Methods: Consecutive liquid-based cytology specimens of 95 LSIL smears were selected and stained for p16INK4a. All patients had colposcopically directed punch biopsies or large loop excision of the transformation zone of the cervix. The endpoint was detection of a biopsy-confirmed CIN2 or worse. Results: The overall sensitivity and specificity of p16INK4a for diagnosis of CIN2+ among LSIL smears were 41% and 86%, respectively. The positive predictive value of the biomarker was 62% and the negative predictive value 72%. Conclusions: The study shows that p16INK4a has low sensitivity but acceptable specificity for evaluation of LSIL smears harbouring high-grade lesions. The marker needs to be further assessed as an adjunct to other tests in an attempt to improve the triage of LSIL cytology smears.
Keywords
p16INK4a
Immunostaining
Cervix
Liquid-based cytology
LSIL
CIN
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