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Factors affecting recurrence and disease-free survival in granulosa cell tumors of the ovary
A. C. Iyibozkurt1,*, S. Topuz1, F. Gungor1, S. E. Akhan1, F. Demirci2, Y. Salihoglu1, S. Berkman1, E. Bengisu1
1 Department of Obstetrics and Gynaecology, Istanbul Faculty of Medicine, Istanbul University, Istanbul (Turkey)
Eur. J. Gynaecol. Oncol. 2010, 31(6), 667–671;
Published: 10 December 2010
Purpose of Investigation: To determine risk factors for prognosis and recurrence in ovarian adult-type granulosa cell tumor (GCT). Methods: A retrospective review of GCT cases treated at our university hospital between 1991-2006. Results: Of 39 patients with GCT, 82% had Stage I disease. The median follow-up period was 71 months. There were 12 cases of recurrence (30.8%) and seven of them had died of disease. The pelvis and liver were the most common sites of recurrence (8 and 3 patients, respectively). Interestingly lymph node recurrence was encountered in two patients. Estimated disease-free survival for five years was 82%. Stage and presence of residual tumor were calculated to be the only associated risk factors for recurrence and prognosis (p < 0.05). Conclusion: Recurrences in GCT might be associated with stage and presence of residual tumor during primary surgery. Although rarely present during diagnosis, lymph node metastasis might be more common in recurrent disease.
Granulosa cell tumor