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Cite this article
Comparison of histopathologic classification and surgical stage by cytokeratin 8 and cytokeratin 18 in endometrial cancer
1 Departments of Pathology, University of Osmangazi School of Medicine, Eskisehir
2 Departments of Gynecology and Obstetrics, University of Osmangazi School of Medicine, Eskisehir
3 Departments of Biostatistics, University of Osmangazi School of Medicine, Eskisehir (Turkey)
Eur. J. Gynaecol. Oncol. 2010, 31(6), 641–644;
Published: 10 December 2010
Purpose of investigation: The aim of the study was to show the role of the cytoskeletal proteins CK8 and CK18 in endometrial cancer invasion and to histopathologically classify endometrial cancer patients. Methods: This study was a prospective analysis of 49 histologic samples of consecutively surgically operated endometrial cancer patients. After histopathologic classification the most invasive tumor area was selected for immunohistochemistry. Monoclonal antihuman keratin Ab-4 and keratin Ab-1 were applied. Results: CK8 and CK18 stained tumoral tissue and tumoral cell debris in the lymphovascular space were significantly correlated with stage (p _ 0.005). Conclusions: To understand the causes of early treatment failure in endometrial cancer patients, further studies are needed to show the role of enhancing factors of endometrial cancer invasion.