IMR Press / EJGO / Volume 31 / Issue 6 / pii/1630990935560-669264293

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Comparison of histopathologic classification and surgical stage by cytokeratin 8 and cytokeratin 18 in endometrial cancer
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1 Departments of Pathology, University of Osmangazi School of Medicine, Eskisehir
2 Departments of Gynecology and Obstetrics, University of Osmangazi School of Medicine, Eskisehir
3 Departments of Biostatistics, University of Osmangazi School of Medicine, Eskisehir (Turkey)
Eur. J. Gynaecol. Oncol. 2010, 31(6), 641–644;
Published: 10 December 2010
Abstract

Purpose of investigation: The aim of the study was to show the role of the cytoskeletal proteins CK8 and CK18 in endometrial cancer invasion and to histopathologically classify endometrial cancer patients. Methods: This study was a prospective analysis of 49 histologic samples of consecutively surgically operated endometrial cancer patients. After histopathologic classification the most invasive tumor area was selected for immunohistochemistry. Monoclonal antihuman keratin Ab-4 and keratin Ab-1 were applied. Results: CK8 and CK18 stained tumoral tissue and tumoral cell debris in the lymphovascular space were significantly correlated with stage (p _ 0.005). Conclusions: To understand the causes of early treatment failure in endometrial cancer patients, further studies are needed to show the role of enhancing factors of endometrial cancer invasion.
Keywords
Endometrial cancer
CK8
CK18
Immunohistochemistry
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