IMR Press / EJGO / Volume 31 / Issue 6 / pii/1630990934143-1494736382

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Repeat low-grade squamous intraepithelial cytology with unsatisfactory colposcopy treated by the loop electrosurgical excision procedure: a retrospective study
Show Less
1 Department of Minimally-invasive Gynecology, Beijing
2 Department of Gynecology Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing (China)
Eur. J. Gynaecol. Oncol. 2010, 31(6), 632–635;
Published: 10 December 2010

Investigation: To evaluate the value of the loop electrosurgical excision procedure (LEEP) for repeat low-grade squamous intraepithelial lesions (LSIL) with unsatisfactory colposcopy and the outcomes of postconization. Methods: We performed LEEP in 136 patients and followed them up with colposcopy, cytology, and high-risk HPV (HR-HPV) detection using Hybrid Capture II (HCII). Results: 55.1% of women had CIN 1 in the specimen, 17.6% had CIN 2-3, and 27.2% had no lesion. The sensitivity of detecting persistent/recurrent disease can reach 90.9% when positive post-treatment HR-HPV or first abnormal cervical cytology after LEEP are found, and the specificity is 95.3% when positive post-treatment HR-HPV coexisting with first abnormal cervical cytology after LEEP are detected. Conclusion: Repeat LSIL with unsatisfactory colposcopy implies a significant risk of CIN 2-3. LEEP is a rational option to those patients with high-risk HPV infection or dysplastic endocervical curettage. Post-treatment follow-up of patients should include both cytology and HR-HPV testing.
Low-grade squamous intraepithelial lesion
Loop electrosurgical excision
Cervical cytology
Human papillomavirus testing
Back to top