IMR Press / EJGO / Volume 31 / Issue 5 / pii/1630985441706-2090550161

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
The relationship between Bcl-2 oncogene expression and clinicopathological criteria in various stages of cervical neoplasia in Egyptian women
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1 Department of Obstetrics and Gynaecology, Crosshouse Hospital, Kilmarnock (U.K.)
2 Department of Obstetrics and Gynaecology, Ain Shams University, Cairo (Egypt)
These authors contributed equally.
Eur. J. Gynaecol. Oncol. 2010, 31(5), 536–538;
Published: 10 October 2010
Abstract

Purpose: To assess the degree of bcl-2 expression in the various stages of cervical neoplasia in a sample population of Egyptian women and relate the findings to clinicopathological criteria of invasive cervical cancer. Methods: Bcl-2 protein expression was assessed by immuno-histochemistry in 40 patients with cervical neoplasia (intraepithelial and invasive) in comparison to 20 patients with benign changes. Patients with invasive disease were followed up 2 years later and the outcome was correlated to the bcl-2 status at the time of diagnosis. Results: Bcl-2 expression increased from 20% in normal cervical tissue to 42.9% in cervical intraepithelial neoplasia grade II then dropped to 33% in invasive disease. Bcl-2 was not expressed (0%) in patients with advanced disease stage and grade nor in patients with lympho-vascular space invasion. Conclusion: Bcl-2 expression is reduced along the spectrum from benign towards invasive disease of the cervix. The maximum expression found in CIN II may suggest increased potential of progression to CIN III.
Keywords
Bcl-2 protein
Cervical intraepithelial neoplasia
Apoptosis
Cancer of uterine cervix
Cervix squamous cell carcinoma
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