IMR Press / EJGO / Volume 31 / Issue 5 / pii/1630985439472-1080512756

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Initial analysis of relationship between plasma platinum concentration and hematological adverse reaction associated with weekly chemotherapy using nedaplatin in combination with radiotherapy for cervical carcinoma
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1 Department of Pharmacy, Kitasato University Hospital, Kitasato, Sagamihara, Kanagawa
2 School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Horinouchi, Hachioji, Tokyo
3 Department of Radiology, Kitasato University School of Medicine, Kitasato, Sagamihara, Kanagawa
4 Department of Obstetrics and Gynecology, Kitasato University School of Medicine, Kitasato, Sagamihara, Kanagawa (Japan)
Eur. J. Gynaecol. Oncol. 2010, 31(5), 517–521;
Published: 10 October 2010
Abstract

Purpose: Established therapeutic guidelines for cervical carcinoma recommend concurrent chemo- and radiotherapy as standard treatment for locally advanced cervical carcinoma. Nedaplatin (CDGP) is a platinum agent developed in Japan that is less nephrotoxic than cisplatin (CDDP), but with equivalent antitumor potency. In the standard dosage regimen for cervical carcinoma, CDGP is administered once every four weeks (monthly regimen). We investigated the efficacy and safety of a new dosage regimen, in which CDGP was administered once weekly for five weeks (weekly regimen). Methods: We measured plasma platinum concentration of patients after administration of CDGP, and analyzed the relationship between plasma platinum concentration and hematological adverse reactions such as thrombocytopenia and leucopenia. Results: The relative rates of change in platelet and white blood cell counts tended to increase as the plasma concentration of platinum increased. Furthermore, the rate of change in platelet counts in relation to the area under the curve was greater for the monthly regimen as compared to weekly. On the other hand, the relative rates of change in WBC were nearly the same between the regimens. Conclusions: These findings indicate that when using chemotherapy with CDGP for a patient with a cervical carcinoma, a weekly regimen might reduce the severity of thrombocytopenia, while still exhibiting the same therapeutic efficacy as the monthly regimen.
Keywords
Cervical carcinoma
Nedaplatin
Chemotherapy
Adverse reaction
Thrombocytopenia
Leucopenia
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