IMR Press / EJGO / Volume 30 / Issue 5 / pii/2009141

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Case Report

Primary clear cell carcinoma of the peritoneum: report of two cases and a review of the literature

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1 Department of Obstetrics and Gynecology, National Defense Medical College, Tokorozawa (Japan)
2 Department of Laboratory Medicine, National Defense Medical College, Tokorozawa (Japan)
3 Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Hidaka (Japan)
4 Department of Gynecology, Ohki Memorial Kikuchi Cancer Clinic for Women, Tokorozawa (Japan)
Eur. J. Gynaecol. Oncol. 2009, 30(5), 575–578;
Published: 10 October 2009

The most common neoplasms of the peritoneum are malignant mesothelioma and serous papillary adenocarcinoma. Clear cell carcinoma (CCC) is mostly derived from the ovary and often associated with endometriosis. We describe the clinicopathologic features of two cases diagnosed as CCC of the peritoneum origin. Case 1, a 53-year-old woman, presented with upper abdominal and pelvic tumors. Case 2, a 66-year-old woman, presented with massive ascites and abdominal tumor. The ovaries and uterine endometrium of these cases were not affected, and the tumors were diagnosed as Stage IIIc CCC of the peritoneum origin. Pathologically, endometriosis was not observed in either case. Adjuvant chemotherapy using irinotecan and cisplatin was effective in one case. The cases and a review of the literature suggested that residual tumor volume size determines the survival of these patients, and that the tumors show resistance to conventional platinum-based chemotherapy. 

Clear cell carcinoma
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