IMR Press / EJGO / Volume 30 / Issue 5 / pii/2009134

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

The role of endothelin-1 and its correlation with CA125 levels, grayscale ultrasonography and Doppler findings in differential diagnoses of ovarian tumors

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1 Division of Gynecological Surgery, Department of Gynecology, Obstetrics and Gynecological Oncology, University of Medical Sciences, Poznan (Poland)
2 Department of Neurochemistry and Neuropathology, Chair of Neurology, University of Medical Sciences, Poznan (Poland)
Eur. J. Gynaecol. Oncol. 2009, 30(5), 552–556;
Published: 10 October 2009

 Purpose of investigation: Assessment of endothelin-1 (ET-1) level for the differential diagnosis of ovarian tumors was performed. Methods: Fifty-three women with ovarian tumors (12 malignant, 41 benign) treated at the Division of Gynecological Surgery, Poznan, Poland were analyzed. ET-1 serum levels were compared with CA125 and Doppler parameters (RI, PI, PSV). The differences were evaluated using the unpaired t-test with Welch’s correction (p < 0.05). Results: There was statistically significant difference in ET-1 levels between the ovarian cancer and benign tumor groups (3.130 pg/ml and 1.819 pg/ml, respectively). The ROC area for ET-1 and CA125 were 0.727 and 0.791, respectively. A negative linear correlation between the level of ET-1 and RI and a positive linear correlation between the level of ET-1 and PSV in the ovarian cancer group were found. Conclusion: ET-1 as a new biomarker for predicting ovarian cancer is not satisfying. A correlation between ET-1 levels and Doppler parameters is very interesting and its role in angiogenesis should be studied extensively. 

Differential diagnosis
Ovarian cancer
Tumor markers
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