European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Primary ovarian leiomyosarcoma associated with Brenner tumor
Background: Primary ovarian leiomyosarcoma (POL) is rare. To the best of our knowledge, POL associated with a Brenner tumor has not been previously documented. Case: A case of POL associated with a Brenner tumor is reported. Although the poorly differentiated component of the tumor was negative for SMA, the presence of spindle cells in the higher differentiated component with fascicle arrangement and immunoreactivity for SMA and strong staining of a poorly differentiated component for desmin and vimentin established the diagnosis. Conclusion: This case indicates that since malignant tumor cells may lose some antigen markers, thorough sampling and immunohistochemistry are necessary. EMA-immunopositivity only could not preclude the diagnosis of leiomyosarcoma.