IMR Press / EJGO / Volume 30 / Issue 2 / pii/2009036

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Microsatellite instability and HPV genotype in Polish women with cervical cancer

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1 Department of Medical Oncology, University of Antwerp (UAIUZA), Antwerp (Belgium)
2 Department of Gynaecological Endocrinology, Medical University of Gdansk (Poland)
3 2nd Department Obstetrics & Gynaecology, Medical University of Gdansk (Poland)
4 INVICTA, Prophylactic Centre, Gdansk (Poland)
5 Institute of Pathology, University of Tübingen (Germany)
Eur. J. Gynaecol. Oncol. 2009, 30(2), 166–162;
Published: 10 April 2009

Introduction: Human papillomaviruses (HPVs) are associated with anogenital cancer. Little is known about the prevalence of microsatellite instability (MSI) in cervical cancer. The aim of this study was to investigate the incidence of microsatellite instability in cervical cancer and to see whether there is a relation between MSI, HPV and clinicopathological characteristics in the study population. Results: Using three assays (pU1M/2R, GP5+/6+ and E6-nested multiplex PCR) HPV was detected in 110 out of 113 patients with histologically confidened cervical cancer. The presence of MSI was investigated in 95 of the 113 cases using seven microsatellite loci. In total, 12 out of the 95 patients (12.6%) showed MSI. None of clinicopathological parameters showed a significant difference between microsatellite stable and MSI cases. Conclusion: In this population of Polish cervical cancer patients, 12.6% showed microsatellite instability. There was no correlation between MSI positivity and clinicopathological parameters and/or survival.

Cervical cancer
Microsatellite instability
Clinicopathological parameters
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