IMR Press / EJGO / Volume 30 / Issue 2 / pii/2009032

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Fas/CD95 promoter polymorphism gene and its relationship with cervical carcinoma

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1 Department of Gynecology, Federal University of São Paulo, Paulista School of Medicina, São Paulo
2 School of Medical Science, São Paulo, City University (UN/CID) and Leonor Mendes de Barros Maternity Hospital, State Secretariat of Health (Brazil)
3 Department of Oncology and Radiotherapy, Turku University Hospital (Finland)
Eur. J. Gynaecol. Oncol. 2009, 30(2), 142–144;
Published: 10 April 2009
Abstract

Objective: Apoptosis is an important fail-safe control in human papillomavirus (HPV)-associated carcinogenesis. We tested the hypothesis that the A/G polymorphism at -670 of Fas promoter is associated with an increased risk for cervical cancer, using a matched case-control setting. Methods: The material in this case-control study consisted of 91 patients with cervical carcinoma and 176 population-based control subjects, recruited between 2002 and 2004; all the ethnic Brazilian women had histologically confirmed cervical carcinoma. Control subjects were agematched; healthy women who were selected following a negative cervical cytology and normal colposcopy. Fas genotyping was performed using a PCR-RFLP technique. Results: No significant difference existed in the distribution of the Fas polymorphisms (wild, heterozygous, mutant) between the cases and controls. The heterozygous (OR: 4.85, 95% CI: 1.1-22.6) genotypes among the younger (<48 yrs) cancer patients were almost 5-fold increased, as compared with the wild type. No such increase was observed among the patients older than 48 years. Conclusions: Our data suggest that 670A/G polymorphism in the promoter region of the death receptor Fas is associated with an increased risk of cervical cancer among Brazilian women under 48 years. The mechanisms would be the inhibition of apoptosis by Fas -670G allele-mediated down-regulation of Fas transcription.

Keywords
Fas
Polymorphism
Apoptosis
Human papillomavirus
Cervical cancer
Risk factor
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