IMR Press / EJGO / Volume 30 / Issue 2 / pii/2009029

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Review

New cytokine: stromal derived factor-1

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1 Department of Gynaecological Oncology; 2Perinathology and Gynaecology Department, Poznan University of Medical Sciences, Poznan (Poland)
Eur. J. Gynaecol. Oncol. 2009, 30(2), 124–127;
Published: 10 April 2009
Abstract

Cytokines are proteins which regulate and control the basic functions of cells, including proliferation, differentiation and migra­tion by auto- and paracrine communication. Chemokines are a family of proinflammatory chemotactic cytokines. Chemokines play a significant role in many physiological and pathological processes. Chemokines usually join many receptors, and the same receptors can join many different chemokines. SDF-1 works by its receptor CXCR4. The SDF-l+CXCR4 complex plays a significant role in the creation of metastases of neoplasms and as a response to cytostatic treatment. Identification of this complex may be a useful prognostic factor in the therapy of many types of carcinoma. The ability to block CXCR4 indicates the existence of new targets in breast or ovarian carcinoma treatment as well as in cases of cervical adenocarcinoma.

Keywords
Chemokinesm
Stromal derived factor (SDF-1)
CXCR4
Complex SDF-1-CXCR4
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