European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
How to determinate the histologic grade in ovarian carcinomas?
In a review of 32 ovarian carcinomas, different grading methods (Broders’ method, mitotic index, nuclear grading, structural grading and histochemical grading) are employed and compared with them and with clinico-pathologic stage. Better prognostic histologic evaluation is given by employ of nuclear grading. Difficulties and reliability of the other grading methods are discussed. The management of ovarian tumours represents a complex and controversal field in gynecologic oncology. Histogenetic definition and useful staging criteria to classify particularly the common epithelial malignant ovary tumors is not definitely established. The importance of histologic differentiation grading has been emphasized in the last years by several reports as well as other different stadiation methods (3-5, 7, 9-11). Nevertheless an exact prognostic evaluation of histologic grading is not easily carried out by very few observations of various controlled series. It depends primary by general low incidence of the ovarian neoplasms, and secondarly by the necessity of prospective studies on cases uniformly evaluated and treated. Of course the possibilities of sampling are reduced. It is very difficult to compare quite different data which are coming from several Surgical Centers with different grading methods, as well as when the same method is used. We can conclude that each Author has his personal manner of judgement. Purpose of this report is to verify the real possibilities of employment of these methods and to know their value to more adequate control of histologic grading.