IMR Press / EJGO / Volume 29 / Issue 5 / pii/1631004256705-1965548752

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Gonadotropins and female sex steroid hormones in cyst fluid and serum from patients with ovarian tumors
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1 Departments of Chemical Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen
2 Departments of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, Nijmegen
3 Current address: Department of Obstetrics and Gynecology, Máxima Medical Centre, Veldhoven (The Netherlands)
Eur. J. Gynaecol. Oncol. 2008, 29(5), 468–472;
Published: 10 October 2008

r > 0.62) with serum concentrations in case of malignant tumors, especially in postmenopausal women, but not in case of benign tumors. The highest gonadotropin concentrations were observed in cyst fluid from malignant ovarian tumors. The most probable explanation for this is an increased vascular permeability within the cysts. Supportive evidence for such an increased vascular permeability is our previous finding of significantly higher VEGF concentrations in cyst fluid from malignant ovarian tumors. The possibility of ectopic production of LH and FSH by malignant ovarian tissue cannot completely be ruled out.
Female sex steroids
Ovarian tumor
Cyst fluid
Menopausal status
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