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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Bcl-2 oncogene expression in estrogen receptor-positive and negative breast carcinoma
1 Department of Pathology, Federal University of Piauí, Teresina, Piauí
2 Department of Gynecology, Federal University of Piauí, Teresina, Piauí
3 Department of Gynecology, Federal University of Sao Paulo, Sao Paulo (Brazil)
Eur. J. Gynaecol. Oncol. 2008, 29(5), 459–461;
Published: 10 October 2008
Purpose: The aim of this study was to evaluate Bcl-2 oncogene expression in estrogen receptor (ER)-positive and negative breast carcinomas. Methods: A study involving 72 cases of infiltrating ductal carcinoma of the breast in postmenopausal women divided into two groups: Group A (ER positive, n = 37) and Group B (ER negative, n = 35). Immunohistochemical analysis of bcl-2 expression was carried out semiquantitatively based on the percentage of stained tumoral cells and the intensity of staining. The chi-square test was used in the statistical analysis of the data and significance was established at p < 0.05. Results: Bcl-2 oncogene expression was statistically greater in tumors of Group A (59.5%) compared to those of Group B (8.6%), (p < 0.001). Conclusion: Bcl-2 had a significantly greater expression in the ER-positive breast tumors compared to ER-negative tumors.