IMR Press / EJGO / Volume 29 / Issue 4 / pii/1630995701645-2000048921

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Case Report
A rare case of low-grade endometrial stromal sarcoma with myxoid differentiation and atypical bizarre cells
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1 Department of Pathology, Medical Faculty, Gaziantep University
2 Department of Gynecology and Obstetrics, Medical Faculty, Gaziantep University (Turkey)
3 Division of Pathology, Medical Faculty, Edinburgh University (UK)
Eur. J. Gynaecol. Oncol. 2008, 29(4), 397–398;
Published: 10 August 2008
Abstract

Endometrial stromal sarcoma (ESS) is a rare mesenchymal tumor with characteristic histological appearances, consisting of diffuse infiltrate of small uniform endometrial stromal cells with a multinodular arrangement and distinct vascular pattern. Less common variants of ESS include “mixed endometrial stromal and smooth muscle tumors”, “endometrial stromal tumors resembling ovarian sex cord tumors” and “endometrial stromal neoplasms with endometrial glands”, and “aggressive endometriosis”. Rarely do endometrial stromal tumors have a prominent fibrous or myxoid appearance which causes confusion and possible misdiagnosis as myxoid leiomyosarcoma. In this report we present a very unusual subtype of ESS in a 32-year-old woman. The tumor revealed atypical pleomorphic bizarre cells which were stained positive only with vimentin and CD10 in an abundant myxoid matrix. A low-proliferative rate was established with MIB-1 staining. To our knowledge such appearance has not been previously reported.
Keywords
Uterus
Endometrial Stromal Sarcoma
Myxoid change
Bizarre cells
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