IMR Press / EJGO / Volume 29 / Issue 4 / pii/1630995696983-1124745370

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Past obstetric history and risk of malignant breast neoplasms
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1 Clinic of Mother’s and Children’s Health, Poznan University of Medical Sciences, Poznan
2 Department of Medical Education, Poznan University of Medical Sciences, Poznan
3 Oncological Clinic, Poznan University of Medical Sciences, Poznan
4 Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan
5 Division of Gynecological Surgery, Poznan University of Medical Sciences, Poznan (Poland)
Eur. J. Gynaecol. Oncol. 2008, 29(4), 374–377;
Published: 10 August 2008
Abstract

Many studies indicate hormonal disorders as a crucial reason for breast pathology. They are also probably responsible for the development of benign neoplasms and play a role in the origin and development of breast carcinoma. Although the mammary gland is under the influence of many steroid and peptide hormones such as thyroid hormones, prolactin, growth hormone, glucocorticosteroids, it is estrogen that plays an important role in the development of breast cancer. The purpose of the study was to analyze the obstetrical past of patients and the potential influence on the risk of developing malignant breast neoplasms. The participants in the study were healthy women with no changes in mammary glands (control group) and women with diagnosed malignant or benign breast neoplasms (study group). The total number of participants was 555 females aged 35-70 years. The study was carried out in the Greater Poland and Lubuskie province between 2005 and 2006. Hormonal disorders in childhood and puberty symptoms of early menarche play a crucial role in increasing the risk of malignant breast neoplasms. In women who experienced one or more miscarriages the risk of malignant breast neoplasms is significantly increased. On the basis of our study we calculated the odds ratio (OR) of malignant breast neoplasms among women who during lactation experienced problems needing medical intervention (OR = 2.25; 95% CI, 1.20-4.19) in comparison to women who experienced no problems).
Keywords
Breast cancer
Risk factors
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