IMR Press / EJGO / Volume 29 / Issue 4 / pii/1630995691697-1959908794

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Stromal cells play a role in cervical cancer progression mediated by MMP-2 protein
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1 Department of Obstetrics and Gynecology, University of São Paulo, Unicamp, Campinas, CP
2 Department of Pathology, State University of Campinas
3 Woman’s Hospital (CAISM), State University of Campinas, University of São Paulo, Unicamp, Campinas, CP
4 Department of Clinical Chemistry and Toxicology, School of Pharmaceutical Sciences, University of São Paulo, Unicamp, Campinas, CP (Brazil)
Eur. J. Gynaecol. Oncol. 2008, 29(4), 341–344;
Published: 10 August 2008

Metalloproteinases, especially metalloproteinase-2 (MMP-2), are known for their role in the degradation of the extracellular matrix. Nevertheless, a thorough understanding of MMP-2 expression in neoplastic lesions of the uterine cervix has yet to be accomplished. This study aimed to analyze the MMP-2 expression in cervical intraepithelial neoplasia III (CIN3) and in cervical squamous cell carcinoma, in tumor cells and adjacent stromal cells. MMP-2 expression was assessed by an immunohistochemical technique. MMP-2 expression was greater in the stromal cells of invasive carcinomas than in CIN3 (p < 0.0001). MMP-2 expression in stromal cells correlates with the clinical stage, gradually increasing as the tumor progresses (p = 0.04). This study corroborates that stromal cells play an important role in tumor invasion and progression, mediated by the progressive enhancement of MMP-2 expression from CIN3 to advanced invasive tumor. The intense MMP-2 expression most probably is associated with poor tumor prognosis.
Matrix metalloproteinase 2
Cervix cancer
Cervical intraepithelial neoplasia
Stromal cells
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