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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Original Research
Self-sampling for human papillomavirus (HPV) testing as cervical cancer screening option. Experience from the LAMS Study
A. Longatto-Filho1,2,*, C. Roteli-Martins3, L. Hammes4, D. Etlinger1, S. M. Miranda Pereira1, M. Erz˘en5, M. Branca6, P. Naud4, S. F. M. Derchain7, L.O. Sarian7, J. Matos4, R. Gontijo7, T. Lima3, M. Y. S. Maeda1, S. Tatti8, S. Syrjänen Syrjänen9, K. Syrjänen Syrjänen10
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1
Instituto Adolfo Lutz, São Paulo (Brazil)
2
Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga (Portugal)
3
Hospital Leonor Mendes de Barros, São Paulo (Brazil)
10
Department of Oncology & Radiotherapy, University of Turku (Finland)
45
SIZE Diagnostic Center, Ljubljana (Slovenia)
89
Department of Oral Pathology, University of Turku (Finland)
60007
Universidade Estadual de Campinas (Brazil)
Eur. J. Gynaecol. Oncol. 2008, 29(4), 327–332;
Published: 10 August 2008
Abstract
Purpose: To compare Hybrid Capture II (HC2) in detecting high-risk (HR) HPV in patient-collected vaginal samples with those obtained using gynaecologist collected samples. Methods: Patients were submitted to Pap smears, visual inspection with acetic acid (VIA) and HC2 for hr-HPV. Results: A total of 1,081 HC2 tests for HR-HPV were performed: 770 (71.2%) samples were collected by a physician and 311 (28.8%) were self-collected by the patients. In detecting any cervical lesion, the sensitivity of HC2 collected by a physician was higher (92.86%) than that (37.5%) in the self-sampling group. Negative predictive value (NPV) was high for both, 99.69% and 93.75%, respectively. Using the CIN2 cutoff, performance of HC2 was significantly improved: 92.9% and 62.5%, respectively. HC2 specificity for any cervical lesion and for CIN2 or higher were close to 90% in both groups. Conclusions: Self-sampled HPV testing is a powerful option to increase the detection of cervical lesions in women segregated from prevention programs.
Keywords
Hybrid capture
HPV
Cervical cancer
Liquid based cytology
Self-sampling