IMR Press / EJGO / Volume 29 / Issue 1 / pii/1630995330891-869251108

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Prognostic factors for the development of vaginal intraepithelial neoplasia
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1 Department of Obstetrics and Gynecology, Hospital Sant Joan de Déu, University of Barcelona, Barcelona
2 Department of Microbiology, Hospital Sant Joan de Déu, University of Barcelona, Barcelona (Spain)
Eur. J. Gynaecol. Oncol. 2008, 29(1), 43–45;
Published: 10 February 2008

Objective: To identify risk factors for the appearance of vaginal intraepithelial neoplasia (VAIN). Material and methods: A total of 485 women with abnormal cytologies were followed over three years (2003-2006). They underwent cytolology and colposcopy, and testing for human papillomavirus virus (HPV) infection. If the colposcopy was atypical, a biopsy was performed. Results: A total of 256 women were treated: 161 by cone biopsy, 103 by LLETZ, 12 by repeat conization, and 44 by total hysterectomy. In eight cases VAIN was diagnosed following hysterectomy. The average age at which VAIN appeared was 49.8 years (age range 39-61). Hysterectomy was indicated in two cases of cervical cancer, four cases of persistent high-grade cervical SIL, and two cases of recurrent high-grade cervical SIL. The mean time for the appearance of VAIN following hysterectomy was 3.8 years (range 1-9 years). Of these eight women, seven had HPV infections at high risk for carcinogenesis. Conclusions: Long-term follow-up cytology is necessary for women treated for high-grade SIL, even after hysterectomy, because of the increased risk of a primary vaginal VAIN lesion, especially in women with high-risk HPV infection.
Vaginal intraepithelial neoplasia
Human papillomavirus
Cervical SIL
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