IMR Press / EJGO / Volume 28 / Issue 5 / pii/2007194

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report

Ovarian clear cell carcinoma associated with endometriosis: a case report with immunohistochemical study

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1 Research Institute of Oncology (IPON)/Discipline of Gynecology and Obstetrics, Brazil
2 Discipline of Endocrinology, Federal University of Triângulo Mineiro (UFTM), Uheraha-MG, Brazil
Eur. J. Gynaecol. Oncol. 2007, 28(5), 403–405;
Published: 10 October 2007

Endometriosis is a frequent benign gynecological disease; nonetheless, it can demonstrate some aspects that resemble malignant disease. Malignant transformation of endometriosis occurs mainly in the ovary. A rare case of transition between typical endometriosis and clear cell carcinoma with immunohistochemical study is presented. The patient, a 30-year-old Caucasian woman (para 0) was diagnosed with endometriosis ten years before. Six months later she developed a left cystic ovarian tumor (58 cm3) that per­sisted after two ultrasounds in a four-month period. Tumor markers were normal (CA125, CA 15.3, CA 19.9, alpha-fetoprotein, car­cinoembrionary antigen Al). There was no ascites. The left ovarian mass was removed by laparotomy and endometriosis in conti­nuity with carcinoma positive for cytokeratin 7 and estrogen receptor was revealed. CD10 was positive in the stromal cells of the endometriosis. Clear cell carcinoma grade 3 was diagnosed. In conclusion, although a rare event, the association of typical endometriosis and clear cell carcinoma of the ovary should be kept in mind, mainly in patients with a persistent ovarian cyst.

Clear cell carcinoma
Immunohistochemical study
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