IMR Press / EJGO / Volume 28 / Issue 4 / pii/2007169

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

The role of p53, Bcl-2 and Ki-67 in premalignant cervical lesions and cervical cancer

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1 Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey
2 Department of Pathology, Ankara University School of Medicine, Ankara, Turkey
Eur. J. Gynaecol. Oncol. 2007, 28(4), 290–293;
Published: 10 August 2007

Purpose: The aim of this study was to determine the role of p53, Bcl-2 and Ki-67 expression in the carcinogenesis of cervical carcinoma and aggressiveness of cervical intraepithelial neoplasia (CIN). Methods: The pathology specimens of 63 patients with a diagnosis of normal squamous epithelium (22 cases), CIN I (14), CIN II (5), CIN III (8) and squamous cell carcinoma (14) were evaluated immunohistochemically for the expression of- p53, Bcl-2 and Ki-67 in paraffin sections. Result: The expression of p53 and Ki-67_increased proportionally to the grade of CIN and cervical cancer, but only the increase of p53 expression was statistically significant (p= 0.002) There was no significant correlation between Bcl-2 expression and premalignant and malignant cervical lesions. Conclusion: p53 expression may have a role in the carcinogenesis of squamous cell cervical carcinoma whereas Bcl-2 expression has no role. Ki-67 expression can not be used in determining the aggressiveness of CIN lesions.

Cervical intraepithelial neoplasia
Cervical cancer
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