IMR Press / EJGO / Volume 28 / Issue 4 / pii/2007165

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Irradiation reduces bleomycin sensitivity in cervical squamous cancer cells in vitro

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1 Department of Obstetrics and Gynecology, Wakayama Medical University, Wakayama, Japan
2 Department of Physiology, Wakayama Medical University, Wakayama, Japan
Eur. J. Gynaecol. Oncol. 2007, 28(4), 272–277;
Published: 10 August 2007
Abstract

Purpose of investigation: The study was performed to examine how bleomycin (BLM) and peplomycin (PEM) should be effec­tively used in radiotherapy for cervical squamous cancer patients. Methods: The effects of BLM on radiosensitivity and the effects of radiation on the sensitivity to BLM of cancer cells were investigated using the radiosensitive human cervical squamous cell carcinoma cell line ME180. Results: BLM treatment did not affect radiosensitivity. However, irradiation significantly reduced cell BLM sensitivity in a dose-dependent manner. There was no significant difference in BLM sensitivity and PEM sensitivity between cells concurrently irradiated and those treated with BLM or PEM 8 h before or 8 h after irradiation. Conclusion: Since sensitivity to BLM is reduced during irradiation, BLM should be administered to cervical cancer patients as an adjuvant chemotherapeutic drug after completion of radiotherapy.

Keywords
Bleomycin
Peplomycin
Cervical cancer
Chemoradiotherapy
Squamous cell carcinoma
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