IMR Press / EJGO / Volume 28 / Issue 3 / pii/2007150

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Postoperative radiotherapy in Stage IB squamous cell cervical cancer

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1 Department of Gynecology and Obstetrics Merkur University Hospital, Croatia
2 Department of Radiation Oncology, Clinical Hospital Centre, Zagreb, Croatia
Eur. J. Gynaecol. Oncol. 2007, 28(3), 211–213;
Published: 10 June 2007
Abstract

Objective: The purpose of the study was to evaluate postoperative whole pelvic radiation for high-risk patients with FIGO Stage IB cervical cancer. Methods: One hundred and forty-eight patients with Stage IB squamous cell carcinoma of the cervix underwent radical hysterectomy and pelvic lymphadenectomy. The low-risk group included patients without unfavorable prognostic factors who were treated only by surgery The high-risk group included women with pelvic node metastases, withpositive or close surgical margins, clinical tumor size> 4.0 cm, depth of stromal invasion > 1/3 the cervical wall, grade 3 tumor and presence of lymphovascular space involvement. High-risk patients received whole pelvic radiotherapy between two and four weeks after surgery Results: Seventy patients (47.3%) were low risk and 78 patients (52.7%) were high risk. Locoregional recurrences were diag­nosed in nine cases (12.8%) in the surgery group and in 11 patients (14.1 %) assigned to radiotherapy. The incidence of distant metastases was 2.8% in the surgery group and 6.4% in the surgery and radiotherapy group. Overall survival at five years was 88.6% in the low-risk group and 84.7% in the high-risk group. Conclusion: Five-year overall survival, locoregional and distant metastases were similar in the low-risk and high-risk groups of patients, thus emphasizing the value of whole pelvic radiation in patients with unfavorable prognostic factor.

Keywords
Stage IB cervical cancer
High-risk patients: Postoperative pelvic radiation
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