IMR Press / EJGO / Volume 28 / Issue 2 / pii/2007136

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Malignant paraganglioma of the urinary bladder in a 44-year-old female: clinicopathological and immunohistochemical study of a rare entity and literature review

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1 Pathology Department, Aretaieion University Hospital, Athens Medical School, Athens, Greece
2 2nd Clinic of Obstetrics and Gynecology, Aretaieion University Hospital, Athens Medical School, Athens, Greece
3 2nd Clinic of Surgery, Aretaieion University Hospital, Athens Medical School, Athens, Greece
Eur. J. Gynaecol. Oncol. 2007, 28(2), 149–151;
Published: 10 April 2007
Abstract

Paraganglioma of the urinary bladder is a rare pathologic entity with no definitive histological, immunohistochemical or molec­ular features to determine its malignant potency. Malignancy is essentially determined by the presence of deep local invasion, inva­sion of adjacent structures, and lymph node or distant metastases. So far, up to 180 cases of paraganglioma have been reported, with less than 30 being malignant. We present a case of malignant paraganglioma of the urinary bladder in a 44-year-old woman. The patient's symptoms were painless hematuria and micturitional headache. The tumor presented the characteristic “zellballen” pattern of growth and immunohistochemically was positive for all neuroendocrine markers. The patient underwent partial cystectomy and the following two postoperative years were uneventful. The literature on paraganglioma of the urinary bladder, analyzing the histo­logical, immunohistochemical and molecular characteristics, is reviewed.

Keywords
Paraganglioma
Urinary bladder
Malignant
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