IMR Press / EJGO / Volume 27 / Issue 6 / pii/2006242

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Epithelial ovarian tumors and CA 125 in premenarchal girls

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1 Department of Pediatric and Adolescent Gynecology, Surgery and Pathology, Mother and Child Health Institute of Serbia, Belgrade, Serbia
2 University Clinic of Gynaecology and Obstetrics Narodni Front, Belgrade, Serbia
Eur. J. Gynaecol. Oncol. 2006, 27(6), 597–599;
Published: 10 December 2006

Purpose: This is a review of our 18-year experience with premenarchal girls with epithelial ovarian tumors. Special attention was focused on the predictive value of CA125 serum levels. Methods: Analysis of premenarchal patients with resected or biopsied ovarian masses from 1988 to 2005 was performed. Patient age, clinical presentation, operative procedures, histologic type of tumor, treatment and outcome were obtained. Results: Six premenarchal girls (aged from 6 to 14 years) were surgically treated for epithelial tumors, representing 13% of all ovarian tumors at this age. Histological findings revealed cystadenoma in four girls, one with a mucinous borderline tumor and one with undifferentiated carcinoma. Tumor volume was higher than 400 cm3 in four girls. Sensitivity, specificity and positive predic­tive value of CA125 level for ovarian malignant epithelial tumors were 0.50, 0.50, and 0.33, respectively. The premenarchal girl with undifferentiated carcinoma in Stage III died after six months in spite of chemotherapy. Conclusion: Ovarian epithelial tumors in premenarchal girls show important growth potential and a relatively high malignancy rate with great influence of borderline neoplasms. CAI 25 is a tumor marker with low sensitivity and specificity for detection of epithelial ovarian malignancy in this age group.

Ovarian carcinoma
Premenarchal girls
CA125 tumor marker
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