IMR Press / EJGO / Volume 27 / Issue 5 / pii/2006232

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Case Report

Squamous cell carcinoma arising in a mature cystic teratoma of the ovary with synchronous invasive lobular breast cancer: case report

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1 First Department of Propaedeutic Surgery, Hippocrateion Hospital, Athens Medical School, Athens, Greece
Eur. J. Gynaecol. Oncol. 2006, 27(5), 537–540;
Published: 10 October 2006

Malignant transformation of a mature ovarian cystic teratoma is the most serious complication of this relatively common neo­plastic lesion. While any constituent tissue of the teratoma can undergo malignant transformation, squamous cell carcinoma repre­sents approximately 80% of those malignancies. Furthermore, the synchronous occurrence of a second malignancy in that setting is extremely rare. Preoperative diagnosis of malignant transformation within a mature cystic teratoma is extremely difficult and poses a great chal­lenge to current clinical surgical practice. The particularly aggressive behavior of this rare tumor, also poses significant surgical managing dilemmas. We present a case report of a premenopausal woman with an invasive squamous cell carcinoma arising in a mature cystic ter­atoma and a synchronous invasive lobular carcinoma of the breast.

Mature cystic teratoma
Squamous cancer
Synchronous neoplasia
Multiple gynecological cancers
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