IMR Press / EJGO / Volume 27 / Issue 5 / pii/2006223

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Endometrial carcinoma and diabetes revisited

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1 Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupoli, Greece
2 Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
3 Department of Obstetrics and Gynecology, Democritus University of Thrace, Alexandroupolis, Greece
Eur. J. Gynaecol. Oncol. 2006, 27(5), 505–508;
Published: 10 October 2006
Abstract

Objective: To investigate whether endometrial adenocarcinomas are intrinsically different in diabetic as compared to non-diabetic patients. Methods: A series of 208 patients with histologically confirmed endometrial adenocarcinomas were divided into groups of diabetic (n = 63) and non-diabetic (n = 145) patients. The two groups were compared in terms of tumor morphology, FIGO stage, clinical risk factors and 12-year survival. Results: A history of a second neoplasia was significantly more frequent in diabetic than in non-diabetic patients (p = 0.001), but other endometrial cancer associated characteristics, such as tumor morphology, FIGO stage, obesity, hypertension, nulliparity, estro­gen use and menopausal status did not differ between the groups. More importantly, the two groups had a similar 12-year survival rate (p = 0.8742). Conclusions: A second neoplasia occurred significantly more frequently in diabetic than in non-diabetic patients with endome­trial carcinoma, but long-term survival and other clinical and histological features were the same in the two groups. These results indicate that endometrial adenocarcinoma is not intrinsically different in diabetic patients.

Keywords
Diabetes mellitus
Endometrial carcinoma
Risk factors
Survival
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