IMR Press / EJGO / Volume 27 / Issue 4 / pii/2006194

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Is dosage of hormone replacement therapy related with endometrial polyp formation?

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1 Technological Educational Institution of Athens, Greece
2 Department of Obstetrics and Gynaecology, ‘Elena Benizelou’ Hospital, Athens, Greece
3 Department of Obstetrics and Gynaecology, University of Athens, ‘Alexandras’ Hospital, Athens, Greece
4 Department of Obstetrics and Gynaecology, University of Patras, Patras, Greece
Eur. J. Gynaecol. Oncol. 2006, 27(4), 393–394;
Published: 10 August 2006
Abstract

Purpose of investigation: to evaluate the effect of different doses of hormone replacement therapy (HRT) on endometrial polyp formation. Methods: 398 menopausal women were initially evaluated through transvaginal ultrasound and patients who already had endome­trial polyps were excluded from the study. One hundred and six (26.6%) eligible patients were enrolled and randomized into two groups of 53 patients to receive two different doses of HRT. Results: six patients with endometrial polyps were detected in the first group and one patient in the second one (p = 0.0502 for total chi-square and p = .1172 for chi-square with continuity correction) after a mean duration of treatment of 26 months and 28,5 months, respectively. There was no difference in the mean number or the mean volume of the polyps between the two subgroups with positive results. Conclusion: Our study showed that endometrial polyp formation may be related with HRT dosage.

Keywords
Hormone replacement therapy (HRT)
Endometrial polyp
Menopausal women
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