IMR Press / EJGO / Volume 27 / Issue 4 / pii/2006193

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Immunohistochemical evaluation of PTEN protein in patients with endometrial intraepithelial neoplas1a compared to endometrial adenocarcinoma and proliferative phase endometrium

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1 Department of Obstetrics and Gynecology, Ege University Faculty of Medicine, Izmir, Turkey
2 Department of Pathology, Ege University Faculty of Medicine, Izmir, Turkey
Eur. J. Gynaecol. Oncol. 2006, 27(4), 389–392;
Published: 10 August 2006

Objective: The aim of this study was to reclassify endometrial hyperplasia cases and examine PTEN protein immunoreactivity compared to cases with endometrial adenocarcinoma and proliferative endometrium. Design: Endometrial samples from 37 women with endometrial hyperplasia with atypia were reclassified as endometrial intraep­ithelial neoplasia (EIN). Eighteen were complex and 19 were simple endometrial hyperplasia. Twenty-our cases of EIN, ten endome­trial adenocarcinoma cases and ten proliferative phase endometrium sections were immunostained for PTEN expression. PTEN expression was documented according to the degree of immunoreactivity as complete loss, partial loss and present. Results: Twenty-four of 37 (64%) women with endometrial hyperplasia were reclassified as EIN. Complete loss of PTEN immunoreactivity was found in only one of the 24 EIN patients (4.2%), partial loss in eight of 24 (33.3%) and present in 15 of 24 (62.5%). There were no difference in PTEN immunoreactivity between EIN, endometrial adenocarcinoma and endometrial prolif­eration (p = 0.342). PTEN immunoreactivity was partially lost in seven and present in three of the patients with endometrial ade­nocarcinoma. None of the patients expressed complete loss of PTEN immunoreactivity in this group. Conclusion: EIN classification may provide a better and more objective assessment of endometrial hyperplasia cases. PTEN expression showed no differences among the cases of EIN, endometrial carcinoma and proliferative phase endometrium.

Endometrial intraepithelial neoplasia
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