IMR Press / EJGO / Volume 27 / Issue 4 / pii/2006186

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Preliminary results of mitomycin C local application as post-treatment prevention of vaginal radiation-induced morbidity in women with cervical cancer

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1 Gynaecological Radiotherapy Department, Copernicus Memorial Hospital, Lodz, Poland
2 Department of Oncology, University of Medical Sciences, Poznan, Poland
3 Chair of Oncology Medical University in Lodz, Poland
Eur. J. Gynaecol. Oncol. 2006, 27(4), 356–358;
Published: 10 August 2006

Purpose: To determine the usefulness of local mitomycin C application in the prophylaxis of vaginal narrowing after irradiation. Material and methods: 31 patients with advanced cervical cancer qualified for the study. They underwent brachytherapy with iridium-192 isotope and external beam therapy with linear accelerators. In a blind probe method 16 patients were chosen to have an aqueous solution of mitomycin C applied to the vagina. Results: Radiotherapy caused a shortening of vaginal length in both groups (study and control). In the “mitomycin C group” com­plete vaginal occlusion was visibly less frequent as were solid fibrotic vault changes. Conclusions: This mode of morbidity prevention can potentially diminish the occurrence of local vaginal fibrosis and thus may improve patients' quality of life. Further investigations are needed to confirm these results.

Cervical cancer
Mitomycin C
Vaginal fibrosis
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