IMR Press / EJGO / Volume 27 / Issue 3 / pii/2006159

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Efficiency of three surgical procedures in eliminating high­risk human papillomavirus infection in women with precancerous cervical lesions

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1 Department of Obstetrics and Gynecology, University Medical Centre Ljubljana, Ljubljana, Slovenia
2 Department of Obstetrics and Gynecology, University Medical Centre Ljubljana, Ljubljana, Slovenia
Eur. J. Gynaecol. Oncol. 2006, 27(3), 239–242;
Published: 10 June 2006
Abstract

Purpose of investigation: To establish the efficiency of laser vaporization (LV), large loop excision of the transformation zone (LLETZ) and cold knife conization, done for precancerous cervical lesions, in eliminating high-risk human papillomavirus (HPV) infection. Additionally, we determined whether the same HPV genotype persisted after surgery. Methods: A total of 214 women were tested for HPV infection by the Hybrid Capture II (HCII) test prior to surgery. HPV-posi­tive women were followed by HCII test ten months after surgery. In persistently HPV-positive women, HPV genotypes were deter­mined by PCR - PGMY09/PGMY 11. Results: The HCII test showed elimination of HPV infection after LV, LLETZ and cold knife conization in 67.6%, 86.3%, and 100% (p < 0.05) of women, respectively. In seven (38.9%) women a different HPV genotype was found to be present after surgery, the corrected efficiency thus being 79.4%, 92.7% and 100% (p = NS), respectively. Conclusions: The three analyzed surgical procedures are effective in eliminating high-risk HPV infection. HPV testing is useful at follow-up, since it can identify a small proportion of women requiring close surveillance and potential treatment.

Keywords
Human papillomavirus
Precancerous cervical lesions
Surgical treatment
Follow-up
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