IMR Press / EJGO / Volume 27 / Issue 1 / pii/2006115

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

The level of antibody against E6 HPV 16 oncoprotein in blood sera of women with chronic HPV 16 infection and cervical cancer

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1 Department of Gynecology and Obstetrics, Division of Gynecological Oncology, Karol Marcinkowski University of Medical Sciences, Poland
2 Department of Molecular Virology Adam Mickiewicz University, Pozńan, Poland
Eur. J. Gynaecol. Oncol. 2006, 27(1), 65–68;
Published: 10 February 2006
Abstract

The aim of this study was to estimate of the role of chronic HPV 16 infection and the presence of anti E6 HPV 16 in the initia­tion of the cancerogenesis process of cervical cancer. Material and Methods: The study included two groups of patients. The first group comprised 323 women observed for three con­secutive years (1998-2000), in whom the presence of HPV 16 viruses was estimated by PCR, and the level of anti E6 HPV 16 anti­bodies was estimated in the plasma with ELISA. A similar test was performed in a group of 46 patients with cervical intraepithe­lial neoplasia (CIN), 91 patients with invasive cervical cancer and 22 women after hysterectomy and RTG-therapy. Results: In 32 patients, chronic HPV 16 infection showed a steady rise in the mean absorbance level of anti E6 HPV 16 anti­bodies from 0.04 in 1998 to 0.06 in 2000, while in HPV-negative women the mean absorbance value was 0.03-0.04. Mean absorbance value in patients with CIN III and invasive cancer rose with advancing stage of the cancer process and lowered after completion of oncological treatment. The values were 0.14, 0.33 and 0.13, respectively. Conclusion: The persistence of chronic HPV 16 infection and accompanying steady rise in absorbance index caused by an increase in the level of antiviral antibodies are a clear warning signal preceding in time the histological process of cancerogenesis.

Keywords
Cervical cancer
HPV 16
Chronic infection
Antibody
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