IMR Press / EJGO / Volume 27 / Issue 1 / pii/2006111

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Clinical significance of a negative loop electrosurgical excision procedure, conization and hysterectomy for cervical intraepithelial neoplasia

Show Less
1 Discipline of Gynecology and Obstetrics Federal Universit of Triângulo Mineiro, Uberaba, MG, Brazil
Eur. J. Gynaecol. Oncol. 2006, 27(1), 50–52;
Published: 10 February 2006

Purpose of Investigation: The absence of cervical intraepithelial neoplasia (CIN) in a loop electrosurgical excision procedure (LEEP), cold-knife conization and hysterectomy for treatment of CIN is an occasional finding of uncertain clinical significance. The aim of this study was to estimate the frequency of a negative procedure and its relationship to disease recurrence. Methods: A retrospective study was conducted on 263 specimens from women submitted to the LEEP (n = 142), conization (n = 101) or hysterectomy (n = 20) due to CIN. Results: The frequency of negative conization, LEEP and hysterectomy were, respectively, 15.5%, 19.8% and 25%. Recurrence occurred from 16 to 44 (median = 42) months in women with negative surgical specimens (LEEP or cold knife conization), and after five to 31 (median = 20) months after histological findings of CIN in surgical specimens, respectively, 7.1 % and 1 1.2%. Conclusion: The absence of CIN in those procedures of biopsy-confirmed CIN is a not an uncommon finding. Patients with pos­itive or negative specimens should be carefully followed.

Cervical intraepithelial neoplasia
Loop electrosurgical excision procedure
Negative speci­men
Back to top