IMR Press / EJGO / Volume 27 / Issue 1 / pii/2006108

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Correlation of mammographic appearance and molecular prognostic factors in high-grade breast carcinomas

Show Less
1 Department of Radiology, Patras University Hospital and Ioanninas University Hospital, Rion, Greece
2 Department of Pathology, Patras University Hospital and Ioanninas University Hospital, Rion, Greece
3 Department of Obstetrics-Gynecology, Patras University Hospital and Ioanninas University Hospital, Rion, Greece
4 Department of Surgery, Patras University Hospital and Ioanninas University Hospital, Rion, Greece
5 Department of Medicine - Division of Oncology, Patras University Hospital and Ioanninas University Hospital, Rion, Greece
Eur. J. Gynaecol. Oncol. 2006, 27(1), 39–41;
Published: 10 February 2006
Abstract

The aim of our study was to evaluate the association between the mammographic appearance and the biologic characteristics of high-grade breast carcinomas. Three hundred and twenty patients with breast carcinomas were studied. Histological examination showed 83 (26%) high-grade ductal carcinomas. Immunohistochemistry was carried out by using antibodies against estrogen receptor (ER), progesterone recep­tor (PR), HER-2/neu, p53 and cathepsin D. In 60/83 high-grade carcinomas we studied the mammographic appearance. Asymmetric density with poorly defined margins without microcalcifications was the major mammographic finding in 49/60 (~82%) high-grade ductal carcinomas. HER-2/neu positivity (68.7%) and p53 positivity (48.2%) were statistically correlated with asymmetric density with poorly defined margins without microcalcifications in high-grade carcinomas. We observed loss of ER and PR receptors in 50%, whereas loss of PR receptors was observed in 65% of high-grade breast carcinomas. Cathepsin D (>20%) was detected in 38.5% of high-grade carcinomas. Our findings suggest a significant relationship between mammographic appearance and biologic markers in high-grade breast car­cmomas.

Keywords
Breast carcinoma
Mammographic appearance
Molecular prognostic factors
Share
Back to top