IMR Press / EJGO / Volume 26 / Issue 6 / pii/2005246

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Angiogenesis in squamous intraepithelial neoplasia of the uterine cervix in HIV-seropositive women

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1 Lower Genital Tract Sector of Oncologic Gynecology Discipline, Gynecology Department of Universidade Federal de Sāo Paulo-UNIFESP-EPM, Brasil
2 Pathology Department, Universidade Federal de Silo Paulo-UNIFESP-EPM, Brasil
Eur. J. Gynaecol. Oncol. 2005, 26(6), 615–618;
Published: 10 December 2005

Objectives: This study aimed to quantify angiogenesis in squamous intraepithelial lesions of the uterine cervix in seropositive HIV patients as well as to establish a relationship between vascular density and variations in the CD4+ lymphocyte titer and the viral load of human immunodeficiency virus (HIV). Methods: 125 patients, 55 HIV seropositive and 70 seronegative, were allo­cated with respect to grade of squamous intraepithelial lesion (SIL). The obtained samples were stained with an immunohisto­chemical marker for CD34 antigen and vessel counts were performed in ten consecutive fields at 400x magnification. The seropositive HIV patients were distributed into groups according to the CD4+ index and HIV viral load. Results: Seropositive HIV patients presented a higher mean vascular density (MVD) than the control group, even in the absence of cervical intraepithelial lesions. High­ and low-grade lesions in the presence of HIV seropositivity presented higher MVD than that found in seronegative HIV patients. There was no significant variation in the MVD and CD4+ count ratio or viral RNA-HIV load, except for high grade (H)SIL Conclusions: Infection with HIV influenced angiogenesis of uterine cervix in the presence of squamous intraepithelial lesions and : more significantly in HSIL.

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