IMR Press / EJGO / Volume 26 / Issue 6 / PII/2005243

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Preoperative chemotherapy with irinotecan and mitomycin for FIGO Stage IIIb cervical squamous cell carcinoma: A pilot study

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1 Department of Obstetrics and Gynecology, Wakayama Medical University, Wakayama (Japan)
Eur. J. Gynaecol. Oncol. 2005, 26(6), 605–607;
Published: 10 December 2005
Abstract

Purpose of investigation: Patients with FIGO Stage Illb cervical cancer show cancer propagation to pelvic side walls from the uterus, and the tumors cannot be completely removed by radical hysterectomy. Here, we examined the effects of preoperative irinotecan HCl (CPT-11)-combined chemotherapy on patients with unresectable Stage IIIb cervical squamous cell carcinoma. Methods: Eleven patients agreed to participate in the pilot study and received preoperative chemotherapy. Results: Cervical tumors of all 11 patients showed partial responses in tumor reduction, and radical hysterectomy was success­fully performed in ten patients treated with CPT-11 and mitomycin C (MMC). One patient treated with CPT-11 and cisplatin had a 68% reduction of the primary cervical lesion but could not undergo radical surgery because of retroperitoneal cancer progression during chemotherapy. Conclusion: These results indicate that chemotherapy with CPT-11 and MMC could be a useful preoperative treatment for unre­sectable Stage IIIb cervical squamous carcinoma.

Keywords
Irinotecan
CPT-11
Cervical cancer
Squamous cell carcinoma
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